pI: 7.2212 |
Length (AA): 198 |
MW (Da): 21151 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 187 | 4e08 (A) | 1 | 186 | 35.00 | 0.000000000019 | 1 | 1.48284 | -1.09 |
2 | 186 | 2rk3 (A) | 3 | 188 | 37.00 | 0 | 1 | 1.47704 | -1.17 |
2 | 198 | 3ot1 (A) | 6 | 200 | 36.00 | 0 | 1 | 1.45925 | -0.89 |
4 | 170 | 1g2i (A) | 2 | 165 | 27.00 | 0 | 1 | 1.26313 | -0.85 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127669)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G14990 | protein DJ-1-like A |
Arabidopsis thaliana | AT1G53280 | DJ1-like protein B |
Babesia bovis | BBOV_I002290 | 4-methyl-5(B-hydroxyethyl)-thiazol monophosphate biosynthesis enzyme, putative |
Brugia malayi | Bm1_07685 | DJ-1 family protein |
Caenorhabditis elegans | CELE_B0432.2 | Protein DJR-1.1 |
Caenorhabditis elegans | CELE_C49G7.11 | Protein DJR-1.2 |
Cryptosporidium hominis | Chro.50218 | CG1349 gene product |
Cryptosporidium parvum | cgd5_1650 | hypothetical protein |
Dictyostelium discoideum | DDB_G0286443 | hypothetical protein |
Drosophila melanogaster | Dmel_CG6646 | CG6646 gene product from transcript CG6646-RA |
Drosophila melanogaster | Dmel_CG1349 | CG1349 gene product from transcript CG1349-RA |
Escherichia coli | b0424 | oxidative-stress-resistance chaperone |
Echinococcus granulosus | EgrG_000135900 | protein DJ 1 |
Entamoeba histolytica | EHI_027600 | 4-methyl-5(B-hydroxyethyl)-thiazol monophosphate biosynthesis enzyme, putative |
Echinococcus multilocularis | EmuJ_000135900 | protein DJ 1 |
Giardia lamblia | GL50803_9088 | 4-methyl-5-thiazole monophosphate biosynthesis enzyme |
Homo sapiens | ENSG00000116288 | parkinson protein 7 |
Leishmania braziliensis | LbrM.30.0870 | 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein, putative |
Leishmania donovani | LdBPK_300800.1 | 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein, putative |
Leishmania infantum | LinJ.30.0800 | 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein, putative |
Leishmania major | LmjF.30.0750 | 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein, putative |
Leishmania mexicana | LmxM.29.0750 | 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein, putative |
Loa Loa (eye worm) | LOAG_06487 | DJ-1 family protein |
Mus musculus | ENSMUSG00000028964 | Parkinson disease (autosomal recessive, early onset) 7 |
Neospora caninum | NCLIV_051530 | hypothetical protein |
Oryza sativa | 4324581 | Os01g0217800 |
Oryza sativa | 4341205 | Os06g0531200 |
Plasmodium berghei | PBANKA_1126200 | protein DJ-1, putative |
Plasmodium falciparum | PF3D7_0627500 | protein DJ-1 |
Plasmodium knowlesi | PKNH_1122300 | protein DJ-1, putative |
Plasmodium vivax | PVX_114480 | protein DJ-1, putative |
Plasmodium yoelii | PY04638 | Drosophila melanogaster CG1349 gene product |
Schistosoma japonicum | Sjp_0008070 | ko:K05687 protein DJ-1, putative |
Schistosoma mansoni | Smp_082030 | family C56 non-peptidase homologue (C56 family) |
Schmidtea mediterranea | mk4.000453.00 | Protein DJ-1 |
Schmidtea mediterranea | mk4.000453.01 | Protein DJ-1 |
Trypanosoma brucei gambiense | Tbg972.6.1980 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.6.2200 | DJ-1 family protein, putative |
Trypanosoma congolense | TcIL3000_6_1810 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.509047.40 | DJ-1 family protein, putative |
Trypanosoma cruzi | TcCLB.507927.60 | DJ-1 family protein, putative |
Toxoplasma gondii | TGME49_214290 | DJ-1 family protein |
Treponema pallidum | TP0445 | 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme (thiJ) |
Theileria parva | TP03_0100 | 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein, putative |
Trichomonas vaginalis | TVAG_420420 | dj-1 protein, putative |
Trichomonas vaginalis | TVAG_240750 | 4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme, putative |
Trichomonas vaginalis | TVAG_302880 | thij/pfpi, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.2200 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.2200 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.2200 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.2200 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0424 | Escherichia coli | non-essential | goodall |
PBANKA_1126200 | Plasmodium berghei | Dispensable | plasmo |
TGME49_214290 | Toxoplasma gondii | Probably non-essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.